Endocrine Abstracts

Approximately 90% of ovarian cancers are derived from ovarian surface epithelial (OSE) cells and are believed to result from repeated episodes of ovulation-associated injury and repair. A knowledge of the control of OSE cell survival is therefore of major interest regarding our understanding of ovarian cancers. We have previously demonstrated that CREB protein is activated in OSE cells around pre-ovulatory follicles and suggested that this activation may play a role to promote...

The successful establishment of pregnancy is dependent on appropriate embryo development and uterine receptivity. The latter consists of secretory transformation of the glandular epithelial cells followed by decidualisation of the stromal compartment. This phase of the cycle is also characterised by extensive tissue remodelling in the superficial layer of the endometrium in preparation for the invasion and implantation of the proliferating trophoblast cells. Ovarian steroids a...

IntroductionThe process of ovulation is believed to contribute to the majority of ovarian cancers that derive from the ovarian surface epithelium (OSE). The OSE is known to be important for successful ovulation and more recently was shown to be sensitive to inflammatory cytokines such as interleukin-1alpha (IL-1alpha; Human Reproduction: 17:2300-2306).MethodsNormal OSE cells were obtained, with informed conse...

IntroductionBased upon epidemiological evidence linking hyperthyroidism, inflammation of the ovarian surface and increased risk of ovarian cancer development, we have studied thyroid receptor expression in human ovarian surface epithelial cells (hOSE), and examined the possibility that triiodothyronine (T3) may have direct effects on hOSE cells, the origin of the vast majority of ovarian tumours.MethodsHuman ...